The knowledge of Pramipexole dihydrochloride monohydrate

Pramipexole dihydrochloride monohydrate is a generic drug name.Pramipexole dihydrochloride monohydrate is a white to off-white powder substance. Melting starts above 280 ° C under decomposition. Pramipexole dihydrochloride monohydrate more than 20% soluble in water, about 8% methanol, about 0.5% in ethanol and practically insoluble in dichloromethane.
Pramipexole rapidly absorbed and achieves concentrations in about 2 hours. The absolute bioavailability of pramipexole is more than 90%, indicating that it is well absorbed and undergoes little presystemic metabolism. Food does not affect the extent of pramipexole absorption, although the time of maximum plasma concentration (Tmax) is increased by about 1 hour when the drug is taken with a meal.
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