Monday 27 February 2012

the structure of teicoplanin

teicoplanin


Actually,teicoplanin is a mixture of several compounds, five major and four minor. All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1 — a fused ring structure to which two carbohydrates are attached. The major and minor components also involve a third carbohydrate moiety — β-D-glucosamine — and differ only by the length and conformation of a side-chain attached to it.

Teicoplanin makes up of a group of five structures which possess a common aglycone, or core, consisting of seven amino acids which are bound by peptide and ether bonds to form a four ring system. These five structures differ by the identity of the fatty acyl side-chain attached to the sugar. The origin of these seven amino acids in the biosynthesis of teicoplanin was studied by 1H and 13C NMR. In particular, teicoplanin contains 4-hydroxyphenylglycine and 3,5-dihydroxyphenylglycine residues, a chlorine atom attached on each of the tyrosine residues, and three sugar moieties, N-fatty acyl-β-D-glucosamine, N-acetyl-β-D-glucosamine, and D-mannose.


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Wednesday 22 February 2012

the description of Atovaquone

Atovaquone


Atovaquone a chemical compound  belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is manufactured in the US in the liquid form, or oral suspension.
Atovaquone is available as a combination preparation with proguanil that has been commercially available from GlaxoSmithKline since 2000 as Malarone for the treatment and prevention of malaria.
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Thursday 16 February 2012

What can Uracil do?

Uracil, in addition to U G, C, and is one of the four bases of the nucleic acid RNA is represented by the character that is adenine, cytosine, guanine and. In RNA, uracil (U) is coupled to the () adenine via two hydrogen bonds. To DNA, the base uracil is replaced with thymine. Uracil, it is possible for drug delivery and, to use as a medicament. When elemental fluorine is reacted with uracil, 5 - fluorouracil will be generated. 5 - fluorouracil, an anticancer agent to be used to masquerade as uracil during the replication process of the nucleic acid is (antimetabolites). 5 - It is similar in shape to fluorouracil, does not do the same chemical reaction and uracil, RNA synthesis by drugs to eliminate it, to stop the proliferation of cancer cells, inhibits the enzyme replication of RNA.
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Wednesday 15 February 2012

Information related with Pantoprazole sodium


Pantoprazole sodium
Pantoprazole is a proton pump inhibitor drug that inhibits the secretion of stomach acid.
Pantoprazole is created for the short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is usually eight weeks duration, after which, another eight weeks course of treatment should be considered if this is necessary. It can be used as maintenance therapy for long-term use after the initial response is achieved.
This medication may be the results of certain lab tests, such as drug screenings (pantoprazole can cause a false positive result for THC, the psychoactive ingredient of
cannabis.
Pantoprazole sodium is white or almost white crystalline power.It is used for gastric and duodenal ulcers.
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Tuesday 14 February 2012

The knowledge of Sirolimus

Sirolimus
Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). A macrolide, sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Easter Island — an island also known as Rapa Nui, hence the name. It is marketed under the trade name Rapamune by Wyeth. Sirolimus was originally developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties. It has since been shown to prolong the life of mice and might also be useful in the treatment of certain cancers. Studies in vitro in mice and in humans suggest sirolimus inhibits HIV replication through different mechanisms, including downregulation of the coreceptor CCR5 and the inhibition of the induction of autophagy. Sirolimus has also been used in preliminary research to combat progeria, a rare disorder that causes individuals to age at an exceedingly rapid pace, leading to death in the early teenage years due to causes such as heart disease or stroke.
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Monday 13 February 2012

The knowledge of Pramipexole dihydrochloride monohydrate

Pramipexole dihydrochloride monohydrate
Pramipexole dihydrochloride monohydrate is a generic drug name.Pramipexole dihydrochloride monohydrate is a white to off-white powder substance. Melting starts above 280 ° C under decomposition. Pramipexole dihydrochloride monohydrate more than 20% soluble in water, about 8% methanol, about 0.5% in ethanol and practically insoluble in dichloromethane.
Pramipexole rapidly absorbed and achieves concentrations in about 2 hours. The absolute bioavailability of pramipexole is more than 90%, indicating that it is well absorbed and undergoes little presystemic metabolism. Food does not affect the extent of pramipexole absorption, although the time of maximum plasma concentration (Tmax) is increased by about 1 hour when the drug is taken with a meal.

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Tuesday 7 February 2012

Where to buy Glycoderm (P)

Glycoderm (P) helps to restore a damaged lipid barrier and supplies the skin with Natural Moisturizing Factors (NMF).
Glycoderm (P) is a polyvalent, strongly effective moisturizer with a liposomal structure. The plant-derived liposomal bilayers entrap biotechnologically produced hyaluronic acid and natural blossom honey.
INCI-Name: Water, Honey, Phospholipids, Sphingolipids, Hyaluronic Acid
pH range: 3.0–10.0
Dosage: 3.0–5.0%
Solubility: water-soluble
Preservation: Preserved with phenoxyethanol and dehydracetic acid (Na salt).
More information: Glycoderm (P) suppliers,